Sertoli cell-only syndrome | |
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Classification and external resources | |
OMIM | 305700 400042 |
DiseasesDB | 31907 |
eMedicine | med/2104 |
MeSH | D054331 |
Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia [1]) is a disorder characterized by male sterility without sexual abnormality. It is the result of absent seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.[2]
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The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.
Testicular biopsy would confirm the absence of spermatozoa .
Sertoli cell only syndrome is likely multifactorial, and characterized by severely reduced or absent spermatogenesis despite the presence of both Sertoli and Leydig cells. A substantial subset of men with this uncommon syndrome have microdeletions in the Yq11 region of the Y chromosome, an area known as the AZF (azoospermia factor) region. Generally speaking, testosterone and LH levels are normal, but due to lack of inhibin, FSH levels are increased.
Sertoli cell only syndrome is like other non-obstructive azoospermia (NOA) cases are managed by sperm retrieval through testicular sperm extraction (mTESE), micro-surgical testicular sperm extraction (mTESE) , or testicular biopsy.[3] On retrieval of viable sperms this could be used in Intracytoplasmic Sperm injection ICSI
In 1979, Levin described germinal cell aplasia with focal spermatogenesis where a variable percentage of seminiferous tubules contain germ cells.[4] It is important to discriminate between both in view of ICSI.
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